abstract：:In the present study, unopposed oestrogens were given to 184 non-hysterectomized women, for a duration varying from four weeks to 24 months, while the endometrial responses were monitored by transvaginal sonography (TVS) and backed up by endometrial sampling (conducted when the endometrial thickness reached 8 mm (doub...

journal_title：Maturitas

authors： Meuwissen JH,Oddens BJ,Klinkhamer PJ

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate whether a previous fracture is a risk factor for fracture later in life and its association with tobacco smoking, menopausal age and the use of oral contraceptives. This is an epidemiological population study based on a questionnaire. A sample of 10000 women from ...

journal_title：Maturitas

authors： Johansson C,Mellström D

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...

journal_title：Maturitas

authors： Tikkanen MJ

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...

journal_title：Maturitas

authors： Piérard GE,Henry F,Piérard-Franchimont C

更新日期：1996-04-01 00:00:00

abstract：:Menopause marks a time of dramatic hormonal and often social change for women. Both risk factors and health needs are likely to change as women pass through menopause. This paper examines the demographic characteristics of the world population of menopausal and post-menopausal women, and also examines the implication ...

journal_title：Maturitas

authors： Hill K

更新日期：1996-03-01 00:00:00

abstract：:Premature ovarian failure (POF) is common, affecting approximately 1% of women. It is defined as gonadal failure before the age of 40 and patients may clinically present with either primary or secondary amenorrhoea. This review concentrates on the clinical aspects of POF, with sequential discussion on the aetiology an...

journal_title：Maturitas

authors： Davis SR

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To assess the prevalence of climacteric symptoms and the use of hormone replacement therapy in a former eastern European country. All 55-, 57-, 59- and 61-year-old women in Kladno in the Czech Republic were asked to participate in the study. METHOD:In 1993, 1505 women in Kladno of the Czech Republic were se...

journal_title：Maturitas

authors： Nedstrand E,Pertl J,Hammar M

更新日期：1996-02-01 00:00:00

abstract：:Urogenital symptoms associated with estrogen loss can occur episodically throughout a woman's life (e.g. during lactation, during treatment with GnRH agonists, etc.) but it is most common and chronic in duration in postmenopausal women. More than 50% of postmenopausal women experience lack of vaginal lubrication and f...

journal_title：Maturitas

authors： Bachmann G

更新日期：1995-12-01 00:00:00

abstract：:A group of 72 postmenopausal women were treated for 4 weeks with vaginal suppositories containing 0.5 or 1.0 mg of estriol. The two different doses achieved an identical significant improvement of urogenital symptoms, while a dose-related effect seen to be on climacteric complaints, according to a good absorption of e...

journal_title：Maturitas

authors： Bottiglione F,Volpe A,Esposito G,Aloysio DD

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To compare the influence on lipid metabolism of two discontinuous, sequentially combined hormone replacement therapy (HRT) regimens. STUDY DESIGN:In an open, randomized study in 60 women, a full lipid profile including Lp(a) and liver function tests were assessed in a fasting state at the end of treatment cy...

journal_title：Maturitas

authors： Schram JH,Boerrigter PJ,The TY

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...

journal_title：Maturitas

authors： Eiken P,Kolthoff N

更新日期：1995-09-01 00:00:00

abstract：:Fifty postmenopausal women requiring hormone replacement therapy for the treatment of climacteric symptoms were recruited in six centers. All patients received a new combined norethisterone acetate (NETA)/oestradiol (E2)-TTS, (Estragest TTS, Ciba-Geigy Ltd), delivering 0.25 mg NETA and 50 micrograms E2 per day, contin...

journal_title：Maturitas

authors： Oosterbaan HP,van Buuren AH,Schram JH,van Kempen PJ,Ubachs JM,van Leusden HA,Beyer GP

更新日期：1995-04-01 00:00:00

abstract：:Tibolone (Livial) has advantages over other forms of hormone replacement therapy (HRT); it is easy to use and does not induce withdrawal bleeding in postmenopausal women. The evidence for the effect of tibolone on climacteric symptoms is reviewed and shows that tibolone is effective in reducing vasomotor symptoms and ...

journal_title：Maturitas

authors： Ross LA,Alder EM

更新日期：1995-02-01 00:00:00

abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...

journal_title：Maturitas

authors： Nedstrand E,Ekseth U,Lindgren R,Hammar M

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To describe changes in the withdrawal bleeding pattern and endometrial histology during a sequential 17 beta-estradiol-dydrogesterone regimen in postmenopausal women. DESIGN:Open-label, non-comparative, prospective study. SETTING:Gynecological outpatient department of a university hospital. PATIENTS:Twenty...

journal_title：Maturitas

authors： van der Mooren MJ,Hanselaar AG,Borm GF,Rolland R

更新日期：1994-12-01 00:00:00

abstract：:Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time ...

journal_title：Maturitas

authors： Sluijmer AV,Heineman MJ,De Leeuw R,Evers JL

更新日期：1994-11-01 00:00:00

abstract：:We have studied the effect of HRT on breast tenderness in 61 postmenopausal women randomised to oral or transdermal sequential HRT. An untreated reference group of 29 postmenopausal women was studied concurrently. A questionnaire concerning breast tenderness was administered before and after 10, 12 and 24 weeks of tre...

journal_title：Maturitas

authors： Marsh MS,Whitcroft S,Whitehead MI

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. DESIGN:Open-label randomized prospective comparative study. SETTING:Gynecological outpatient department of an university hospital....

journal_title：Maturitas

authors： van der Mooren MJ,Leuven JA,Rolland R

更新日期：1994-05-01 00:00:00

abstract：:A prospective study was conducted amongst Hong Kong Chinese women to determine the incidence of acute menopausal symptoms following surgical menopause. Cases where a laparotomy was performed for other indications were used as controls. Hot flushes and sweating developed in 8/33 (24.2%) and 6/33 (18.2%), respectively, ...

journal_title：Maturitas

authors： Haines CJ,Chung TK,Leung DH

更新日期：1994-03-01 00:00:00

abstract：:In order to assess the possible role of circulating immunoreactive inhibin (INH) during the menopausal transition, two groups of subjects were studied. Four were normal volunteers, three of whom had developed their first symptoms of cycle irregularity at age 45-46 years, the fourth being aged 37, a volunteer for a stu...

journal_title：Maturitas

authors： Hee J,MacNaughton J,Bangah M,Burger HG

更新日期：1993-12-01 00:00:00

abstract：:The present study had two objectives: (1) to register the prevalence of a number of climacteric complaints in a Danish general population cohort and (2) retrospectively to test the validity of an association between climacteric complaints, menopausal development, occurrence of life events and social background. A post...

journal_title：Maturitas

authors： Køster A,Davidsen M

更新日期：1993-11-01 00:00:00

abstract：:This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly mens...

journal_title：Maturitas

authors： Gonzales GF,Carrillo C

更新日期：1993-07-01 00:00:00

abstract：:An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...

journal_title：Maturitas

authors： Haenggi W,Birkhaeuser MH

更新日期：1993-03-01 00:00:00

abstract：:A total of 151 postmenopausal women were randomly allocated to 3 groups for treatment with hormone replacement therapy. One group received combined therapy (2 mg oestradiol (E2) and 1 mg norethisterone acetate (NETA) daily), the second group was placed on sequential therapy (2 mg E2 for 12 days, 2 mgE2 and 1 mg NETA f...

journal_title：Maturitas

authors： Obel EB,Munk-Jensen N,Svenstrup B,Bennett P,Micic S,Henrik-Nielsen R,Nielsen SP,Gydesen H,Jensen BM

更新日期：1993-01-01 00:00:00

abstract：:To prevent hyperplasia and carcinoma of the endometrium during oestrogen replacement therapy (ORT), the addition of progestogens once a month is considered mandatory. However, there is no sound scientific basis for this assumption. As the addition of progestogens has several disadvantages, it is important to minimize ...

journal_title：Maturitas

authors： Meuwissen JH,van Langen H,Moret E,Navarro-Morquecho I

更新日期：1992-08-01 00:00:00

abstract：:The secretory endometrial protein PP14 was measured in serum from 49 healthy, early post-menopausal women receiving continuous combined oestradiol valerate/cyproterone acetate (2 mg E2V + 1 mg CPA daily) or placebo over a period of 2 years. In the hormone group, serum PP14 increased from 2.1 micrograms/l to a maximum ...

journal_title：Maturitas

authors： Byrjalsen I,Thormann L,Riis BJ,Christiansen C

更新日期：1992-08-01 00:00:00

abstract：:Forty-five healthy postmenopausal women participated in a study designed to examine the effects on bone and mineral metabolism of SHD 386L, a new hormone replacement therapy (HRT) regime. This oral preparation delivers 2 mg estradiol valerate daily and 75 micrograms of levonorgestrel from days 17-28 inclusive of a 28-...

journal_title：Maturitas

authors： Purdie DW,Hay AW,Everett M

更新日期：1992-03-01 00:00:00

abstract：:Fifty-six premenopausal women were drawn from a cross-sectional survey of 850 women living in South-East England. They were recontacted 3 years later when 36 met the criterion of being naturally peri- or postmenopausal. Somatic, vasomotor and emotional symptoms, as well as general health, use of medical services and b...

journal_title：Maturitas

authors： Hunter M

更新日期：1992-01-01 00:00:00

abstract：:The menopausal syndrome is characterized by a variety of emotional and physical symptoms of varying intensity. A total of 1287 women who attended the Outpatient Department for Climacteric Symptoms and Osteoporosis Prophylaxis (1st Department of Gynaecology and Obstetrics, University of Vienna Medical School) constitut...

journal_title：Maturitas

authors： Metka M,Enzelsberger H,Knogler W,Schurz B,Aichmair H

更新日期：1991-12-01 00:00:00

abstract：:The endometrial effect of long-term vaginal oestriol (E3) therapy for urogenital atrophy was assessed in 23 post-menopausal women. Hysteroscopic and histological examinations were performed in each patient to assess endometrial atrophy before treatment and after 6 and 12 months of therapy (0.5 mg vaginal E3 for 21 day...

journal_title：Maturitas

authors： Gerbaldo D,Ferraiolo A,Croce S,Truini M,Capitanio GL

更新日期：1991-10-01 00:00:00

abstract：:Climacteric symptoms were investigated among healthy women living in and around a small town in Tanzania. The incidence of symptoms was high and similar to that recorded in Western societies. Statistically significant associations were observed between some symptoms and the number of years since menopause. More attent...

journal_title：Maturitas

authors： Moore B,Kombe H

更新日期：1991-09-01 00:00:00

abstract：:A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch appli...

journal_title：Maturitas

authors： Sentrakul P,Chompootaweep S,Sintupak S,Tasanapradit P,Tunsaringkarn K,Dusitsin N

更新日期：1991-06-01 00:00:00

abstract：:Sera were sampled from 83 people (pre- and post-menopausal women and men). Climacteric symptoms of 23 women were treated with conjugated estrogen. Sera were sampled serially until the 21st day of estrogen administration. Serum concentrations of 40 protein components were measured by micro single radial immunodiffusion...

journal_title：Maturitas

authors： Hashimoto S,Miwa M,Akasofu K,Nishida E

更新日期：1991-03-01 00:00:00

abstract：:The two most important risk factors for maintaining skeletal health are the bone mass obtained at skeletal maturity (peak bone mass) and the subsequent bone loss. Those women with a low peak bone mass and a rapid bone loss are thus at increased risk of developing osteoporosis in the future, and should be identified. T...

journal_title：Maturitas

authors： Christiansen C,Riis BJ

更新日期：1990-09-01 00:00:00

abstract：:Continuous (Kliogest) and sequential (Trisequens) oestrogen-progestogen treatment were compared in a randomized, parallel, group study in women suffering from climacteric symptoms. The subjects were treated with Trisequens for 4 mth prior to randomized assignment to 1 of 2 treatment groups, and with either Trisequens ...

journal_title：Maturitas

authors： Høvik P,Sundsbak HP,Gaasemyr M,Sandvik L

更新日期：1989-03-01 00:00:00

abstract：:Serum concentrations of 17 beta-oestradiol (E2), unconjugated oestrone (E1), total oestrone (tE1), progesterone (P), follicle-stimulating hormone (FSH) and sex-hormone-binding globulin (SHBG) were measured before and after daily intravaginal administration of 250 micrograms micronized E2 and 10 mg micronized P for 14 ...

journal_title：Maturitas

authors： Carlström K,Pschera H,Lunell NO

更新日期：1988-12-01 00:00:00

abstract：:The aim of the study was to investigate the influence of long-term administration of oral contraceptives on bone density in climacteric women. The existence of a correlation between long-term use and bone density was confirmed. ...

journal_title：Maturitas

authors： Enzelsberger H,Metka M,Heytmanek G,Schurz B,Kurz C,Kusztrich M

更新日期：1988-03-01 00:00:00

abstract：:Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...

journal_title：Maturitas

authors： Fletcher CD,Farish E,Dagen MM,Allam BF,Hart DM

更新日期：1988-03-01 00:00:00

abstract：:In Belgium, the contraceptive choices and views on completed family size were studied. The study involved a 2-page questionnaire; the 1st part was self-administered while the 2nd half of the questionnaire allowed for the physician to interview the respondents. The survey studied the demographic characteristics of th...

journal_title：Maturitas

authors： van Keep PA,Dewilde DM

更新日期：1988-01-01 00:00:00

abstract：:Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal...

journal_title：Maturitas

authors： Brincat M,Versi E,O'Dowd T,Moniz CF,Magos A,Kabalan S,Studd JW

更新日期：1987-04-01 00:00:00